Atmaca Murad, Kuloglu Muloglu, Tezcan Ertan, Gecici Omer, Ustundag Bilal
Department of Psychiatry, Firat University, School of Medicine, Elazig, Turkey.
Neuropsychobiology. 2002;45(4):167-71. doi: 10.1159/000063665.
The association between low or lowered cholesterol and impulsivity, aggressive behaviours and suicide remains controversial. In the present study, cholesterol and leptin levels of patients with borderline personality disorder in whom impulsivity, aggressive behaviours and suicide attempts are clearly established have been compared with those of healthy controls. The study group consisted of 16 patients with borderline personality disorder and 16 healthy controls. All patients were assessed with the Barratt Impulsivity Scale (BIS), Buss-Durkee Hostility Inventory (BDHI) and Hamilton Depression Rating Scale (HDRS). Fasting serum cholesterol and leptin levels were measured. The mean cholesterol and leptin levels of the patient group were significantly lower than those of the controls. Likewise, the patients with current suicidal thoughts and a history of suicide attempt had statistically significantly lower cholesterol and leptin levels compared with the patients without those features. There was an inverse correlation between both cholesterol and leptin levels, and impulsivity as determined by the BIS or aggression as determined by the BDHI, but no correlation between both cholesterol and leptin levels and the HDRS was found in the patients. In conclusion, the present study demonstrates that the patients with borderline personality disorder have lower cholesterol and leptin levels than healthy controls. Low serum cholesterol and leptin levels are associated with all dimensions of the disorder - impulsivity, aggression and suicidality - but are not associated with the presence and the severity of comorbid depression.
低胆固醇或胆固醇降低与冲动性、攻击行为及自杀之间的关联仍存在争议。在本研究中，将冲动性、攻击行为及自杀企图明确的边缘型人格障碍患者的胆固醇和瘦素水平与健康对照者进行了比较。研究组由16例边缘型人格障碍患者和16名健康对照者组成。所有患者均接受了巴雷特冲动性量表（BIS）、巴斯-杜克敌意量表（BDHI）及汉密尔顿抑郁评定量表（HDRS）评估。测量了空腹血清胆固醇和瘦素水平。患者组的平均胆固醇和瘦素水平显著低于对照组。同样，有当前自杀念头和自杀企图史的患者与无这些特征的患者相比，胆固醇和瘦素水平在统计学上显著更低。胆固醇和瘦素水平与由BIS所确定的冲动性或由BDHI所确定的攻击性之间均呈负相关，但在患者中未发现胆固醇和瘦素水平与HDRS之间存在相关性。总之，本研究表明，边缘型人格障碍患者的胆固醇和瘦素水平低于健康对照者。低血清胆固醇和瘦素水平与该障碍的所有维度——冲动性、攻击性及自杀倾向——相关，但与共病抑郁的存在及严重程度无关。
