Marcinko Darko, Bilić Vedran, Pivac Nela, Tentor Berislav, Franić Tomislav, Loncar Mladen, Marcinko Vesna Medjedović, Jakovljević Miro
University of Zagreb, Zagreb University Hospital Center, Department of Psychiatry, Zagreb, Croatia.
Coll Antropol. 2011 Jan;35 Suppl 1:219-23.
Findings from numerous studies suggest an association between low cholesterol levels and suicidal behavior in patients with different psychiatric diagnoses. The aims of this case-control study were to test whether cholesterol levels in male suicidal patients (N=20) with borderline personality disorder (BPD) are lower than in male non-suicidal patients (N=20) with BPD and male healthy control group (N=20), and to evaluate the influence of structured individual psychoanalytic psychotherapy on suicidal behavior. The groups were matched for age and body mass index (BMI). Results showed that serum cholesterol levels did not differ significantly between suicidal and non-suicidal BPD patients and healthy controls. The level of psychopathology (measured by Brief Psychiatric Rating Scale and Hamilton Depression Rating Scale) was significantly higher in the group of suicidal patients, which indicates the importance of evaluating particular clinical symptoms in BPD, in order to prevent suicidal behavior. Non-suicidal male patients suffering from BPD received more frequently structured individual psychoanalytic psychotherapy prior to the hospitalization than suicidal group. These results emphasized the role of this type of psychotherapy in preventing suicidal behavior in BPD patients.
大量研究结果表明，在患有不同精神疾病诊断的患者中，低胆固醇水平与自杀行为之间存在关联。本病例对照研究的目的是测试患有边缘性人格障碍（BPD）的男性自杀患者（N = 20）的胆固醇水平是否低于患有BPD的男性非自杀患者（N = 20）和男性健康对照组（N = 20），并评估结构化个体心理分析心理治疗对自杀行为的影响。这些组在年龄和体重指数（BMI）方面进行了匹配。结果显示，自杀和非自杀的BPD患者以及健康对照组之间的血清胆固醇水平没有显著差异。自杀患者组的精神病理学水平（通过简明精神病评定量表和汉密尔顿抑郁评定量表测量）显著更高，这表明在BPD中评估特定临床症状以预防自杀行为具有重要性。患有BPD的非自杀男性患者在住院前比自杀组更频繁地接受结构化个体心理分析心理治疗。这些结果强调了这种心理治疗类型在预防BPD患者自杀行为中的作用。
