Cell and Applied Physiology Group, Department of Basic Sciences, Faculty of Health, Universidad Tecnológica de Pereira, Pereira, Colombia.
Neuropsychiatr Dis Treat. 2013;9:659-66. doi: 10.2147/NDT.S44573. Epub 2013 May 13.
Leptin is a hormone with significant effects on the brain, both at the cellular level and cognitive level. This study aimed to establish the association between leptin levels and delirium in a Colombian elderly population. 115 patients older than 60 years were included. Leptin was measured by enzyme-linked immunosorbent assay after overnight fasting and Mini-Mental State Examination and Confusion Assessment Method (CAM) tests were employed. Delirium was diagnosed using CAM in 23.48% of patients, being most frequent in men. There were no significant differences in hematology and renal test values between patients with delirium and those without delirium, but cerebrovascular diagnoses were more frequent in patients with delirium. No correlation with any specific medication was found, but patients with delirium had a higher number of comorbidities and medications. Leptin levels were significantly lower in patients with delirium and correlated negatively with the number of diagnoses and medications, but not with age, gender, body mass index, or hematology and renal test results. Leptin levels may have a role in the pathophysiological process of delirium and low leptin could be a useful clinical biomarker to establish risk in elderly patients given the association with delirium.
瘦素是一种对大脑具有重要影响的激素，无论是在细胞水平还是认知水平上。本研究旨在建立哥伦比亚老年人群中瘦素水平与谵妄之间的关联。共纳入 115 名年龄大于 60 岁的患者。患者禁食过夜后，采用酶联免疫吸附试验测定瘦素，同时进行简易精神状态检查和意识模糊评估法（CAM）测试。23.48%的患者被诊断为谵妄，男性更为常见。谵妄患者和非谵妄患者的血液学和肾功能检查值无显著差异，但谵妄患者的脑血管病诊断更为常见。未发现与任何特定药物有相关性，但谵妄患者的合并症和用药更多。谵妄患者的瘦素水平显著降低，且与诊断和用药数量呈负相关，但与年龄、性别、体重指数或血液学和肾功能检查结果无关。瘦素水平可能在谵妄的病理生理过程中发挥作用，鉴于其与谵妄的关联，低瘦素可能成为老年患者风险评估的有用临床生物标志物。
