Essner Jeffrey J, Vogan Kyle J, Wagner Molly K, Tabin Clifford J, Yost H Joseph, Brueckner Martina
Center for Children, Huntsman Cancer Institute and Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112-5550, USA.
Nature. 2002 Jul 4;418(6893):37-8. doi: 10.1038/418037a.
How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.
在发育中的脊椎动物胚胎的身体结构中，左右利手性是如何起源的，这是一个备受争议的话题。在小鼠中，左右偏向被认为源于一种定向的细胞外流动（节点流），这种流动是由胚胎节点腹侧表面的单纤毛的动力蛋白依赖性旋转产生的。在这里，我们表明，节点单纤毛的存在以及与纤毛功能相关的动力蛋白基因的表达在广泛的脊椎动物类别中都是保守的，这表明类似的纤毛机制可能是所有脊椎动物中利手性建立的基础。
