Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins.

作者信息

Benoit Evelyne, Mattei Cesar, Ouanounou Gilles, Meunier Frederic A, Suput Dusan, Le Gall Frederic, Marquais Michel, Dechraoui Marie Y, Molgo Jordi

机构信息

Laboratoire de Neurobiologie Cellulaire et Moléculaire, UPR 9040, Institut Fédératif de Neurobiologie Alfred Fessard, CNRS, bat. 32-33, 91198 Gif sur Yvette Cedex, France.

出版信息

Cell Mol Biol Lett. 2002;7(2):317-21.

This review describes the ionic mechanisms involved in the nodal swelling of frog myelinated axons caused by specific marine neurotoxins (ciguatoxins, brevetoxins, Conus consors toxin and equinatoxin-II), analysed using confocal laser scanning microscopy. We have focussed on toxins that either target neuronal voltage-dependent Na+ channels, or that form cation-selective pores and indirectly affect the functioning of the Na(+)-Ca(++)exchanger.