Friedman Melissa A, Fernandez Mercedes, Backer Lorraine C, Dickey Robert W, Bernstein Jeffrey, Schrank Kathleen, Kibler Steven, Stephan Wendy, Gribble Matthew O, Bienfang Paul, Bowen Robert E, Degrasse Stacey, Flores Quintana Harold A, Loeffler Christopher R, Weisman Richard, Blythe Donna, Berdalet Elisa, Ayyar Ram, Clarkson-Townsend Danielle, Swajian Karen, Benner Ronald, Brewer Tom, Fleming Lora E
Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
Department of Psychology and Neuroscience, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.
Mar Drugs. 2017 Mar 14;15(3):72. doi: 10.3390/md15030072.
Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts. The illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months. This paper is a general review of CFP including the human health effects of exposure to ciguatoxins (CTXs), diagnosis, human pathophysiology of CFP, treatment, detection of CTXs in fish, epidemiology of the illness, global dimensions, prevention, future directions, and recommendations for clinicians and patients. It updates and expands upon the previous review of CFP published by Friedman et al. (2008) and addresses new insights and relevant emerging global themes such as climate and environmental change, international market issues, and socioeconomic impacts of CFP. It also provides a proposed universal case definition for CFP designed to account for the variability in symptom presentation across different geographic regions. Information that is important but unchanged since the previous review has been reiterated. This article is intended for a broad audience, including resource and fishery managers, commercial and recreational fishers, public health officials, medical professionals, and other interested parties.
雪卡鱼中毒（CFP）是世界上报告最为频繁的海产品毒素疾病。它会对人类健康、社会和经济造成重大影响。这种疾病会引发一系列复杂的胃肠道、神经和神经心理以及心血管症状，这些症状可能会持续数天、数周或数月。本文是对雪卡鱼中毒的全面综述，内容包括接触雪卡毒素（CTXs）对人类健康的影响、诊断、雪卡鱼中毒的人体病理生理学、治疗、鱼类中雪卡毒素的检测、该疾病的流行病学、全球范围、预防、未来方向以及对临床医生和患者的建议。它更新并扩展了Friedman等人（2008年）之前发表的关于雪卡鱼中毒的综述，并探讨了新的见解和相关的全球新出现的主题，如气候和环境变化、国际市场问题以及雪卡鱼中毒的社会经济影响。它还提供了一个拟议的雪卡鱼中毒通用病例定义，旨在考虑不同地理区域症状表现的差异。自上次综述以来重要但未变的信息已再次提及。本文面向广泛的受众，包括资源和渔业管理人员、商业和休闲渔民、公共卫生官员、医学专业人员以及其他相关方。
