Ting Hua, Liao Jiuan-Miaw, Lin Chih-Feng, Chiang Ping-Yen, Chang Chi-Chen, Kuo Dong-Yih, Lin Tzer-Bin
University Hospital, Chung-Shan Medical University, No. 110 Chang-Kuo North Road, the first Section, Taichung 10018, Taiwan.
Neurosci Lett. 2002 Jul 12;327(1):5-8. doi: 10.1016/s0304-3940(02)00336-1.
The neural mechanism underlying the effect of electroacupuncture (Ea) on arterial blood pressure (BP) and renal nerve activity (RNA) in the intact state and during acute hemorrhage was investigated in anesthetized rats. Two acupoints, Hoku (Li-4, at the junction of the first and the second metacarpal bone) and Tsusanli (St-36, at the lateral upper tibia bone), were tested using Ea of two different frequencies (2 and 20 Hz). In the intact state, Ea at Hoku elicited an elevation of BP in parallel with RNA, while Ea found no response with identical parameters at Tsusanli. The pattern of the pressor response caused by a low frequency Ea (2 Hz) at Hoku was different than a high frequency one (20 Hz), i.e. a tonic effect was elicited with 2 Hz, while a phasic one was induced with 20 Hz. In mild hemorrhage conditions (10% of BP decrease), similar pressor effects, as in intact rats, were also elicited by Ea. However, in severe hemorrhage conditions (20 and 30% BP decrease), Ea induced a pressor effect on RNA and an attenuated effect on BP. BP and RNA showed a significant correlation in intact and mild hemorrhage conditions, but not in severe hemorrhage conditions. All the results suggested that Ea at Hoku with appropriate stimulation parameters can increase and maintain BP in normal and hemorrhage conditions, and such a therapeutic technique has potential in clinical practice.
在麻醉大鼠中，研究了电针（Ea）对完整状态及急性出血期间动脉血压（BP）和肾神经活动（RNA）影响的神经机制。使用两种不同频率（2和20Hz）的电针对两个穴位进行测试，即合谷（LI-4，位于第一和第二掌骨交界处）和足三里（ST-36，位于胫骨外侧上缘）。在完整状态下，合谷穴电针可使血压升高并伴有肾神经活动增强，而相同参数的足三里穴电针无反应。合谷穴低频（2Hz）电针引起的升压反应模式与高频（20Hz）不同，即2Hz引起持续性效应，而20Hz引起阶段性效应。在轻度出血条件下（血压下降10%），电针也能引起与完整大鼠相似的升压效应。然而，在严重出血条件下（血压下降20%和30%），电针对肾神经活动有升压作用，对血压的作用减弱。在完整和轻度出血条件下，血压和肾神经活动显著相关，而在严重出血条件下则无相关性。所有结果表明，合谷穴电针采用适当的刺激参数可在正常和出血条件下升高并维持血压，这种治疗技术在临床实践中有潜在应用价值。
