Liao Jiuan-Miaw, Ting Hua, Lee Shin-Da, Yang Chao-Hsun, Liou Ying-Ming, Peng Mei-Lin, Tsai Shih-Jei, Lin Chih-Feng, Lin Tzer-Bin
Department of Physiology, College of Medicine Chung-Shan Medical University, No. 110, Chang-Kuo North Rd Section 1, Taichung, Taiwan 10018.
Auton Neurosci. 2006 Jan 30;124(1-2):18-25. doi: 10.1016/j.autneu.2005.10.005. Epub 2006 Feb 3.
The effects of electroacupuncture (Ea) on circulatory dynamics were investigated in anesthetized rats. The arterial blood pressure (BP) and the heart rate (HR) in response to Ea stimulations at the Tsusanli point (St-36) and the Hoku point (Li-4) were tested by a low frequency Ea (2 Hz; LFEa) and a high frequency Ea (20 Hz; HFEa) with stimulation intensities 20 times the motor threshold. Neither the HR nor the BP was affected when the Tsusanli point was stimulated. Whereas, Ea stimulations at the Hoku point elicit chronotropic and pressor effects. The patterns of pressor responses caused by the LFEa were different from that of an HFEa, i.e., the LFEa elicited a tonic effect, while an HFEa had a phasic one. The HFEa-induced pressor and chronotropic effects were attenuated, while the LFEa induced effects were completely blocked by an intravenous infusion of an alpha-adrenergic blocker (moxisylyte 0.2 mg/min/kg, i.v., for 20 min). A co-infusion with alpha-and beta-adrenergic blockers (propanolol 0.2 mg/min/kg, i.v., for 20 min) completely blocked the HFEa-induced pressor and chronotropic effects. We concluded that Ea stimulations, at the Hoku acupoint, with appropriate stimulation parameters can increase and maintain BP. Furthermore, the LFEa stimulation activates sympathetic vasomotor tone, whereas the HFEa stimulation causes an additional potentiation on the sympathetic drive to the heart.
在麻醉大鼠中研究了电针（Ea）对循环动力学的影响。通过低频电针（2Hz；LFEa）和高频电针（20Hz；HFEa），以运动阈值的20倍的刺激强度，测试足三里穴（St-36）和合谷穴（Li-4）处电针刺激对动脉血压（BP）和心率（HR）的影响。刺激足三里穴时，HR和BP均未受影响。然而，合谷穴处的电针刺激会引起变时性和升压效应。LFEa引起的升压反应模式与HFEa不同，即LFEa引起持续性效应，而HFEa引起阶段性效应。静脉输注α-肾上腺素能阻滞剂（莫西赛利0.2mg/min/kg，静脉注射，持续20分钟）可减弱HFEa诱导的升压和变时性效应，而LFEa诱导的效应则被完全阻断。α-和β-肾上腺素能阻滞剂联合输注（普萘洛尔0.2mg/min/kg，静脉注射，持续20分钟）可完全阻断HFEa诱导的升压和变时性效应。我们得出结论，合谷穴处的电针刺激，采用适当的刺激参数，可以升高并维持血压。此外，LFEa刺激激活交感缩血管张力，而HFEa刺激会对心脏的交感驱动产生额外增强作用。
