[Effect of vagotomy with conservative stomach resection on the level of blood gastrin].

The concentration of gastrin in blood prior to and after vagotomy, associated with economic gastric resection, was determined radioimmunologically in patients with duodenal ulcerous disease. In patients with ulcerous disease of the duodenum insulin hypoglycemia resulted in an increased gastrin concentration in blood. Vagotomy associated with economic gastric resection has led to disappearance of this effect and to a decrease in the gastrin concentration in blood. There was stated the role of extragastric sources in the production of gastrin and the inhibitory effect of the vagus on the release of gastrin from these sources. Following vagotomy, associated with economic gastric resection, only gastrin produced by extragastric sources is circulating in blood. Vagotomy with economic gastric resection affecting both phases of gastric secretion is a high effective and pathogenetically grounded method of therapy for ulcerous disease of the duodenum.