消化性溃疡患者的胃窦胃泌素细胞增生
Antral gastrin cell hyperplasia in patients with peptic ulcer.
作者信息
Keuppens F, Willems G, De Graef J, Woussen-Colle M C
出版信息
Ann Surg. 1980 Mar;191(3):276-81. doi: 10.1097/00000658-198003000-00004.
The total number of gastrin (G) cells in the stomach was determined by using a histologic counting method and planimetry in ulcerous and nonulcerous patients. The preoperative basal and postprandial serum gastrin values and the gastrin cell mass in the gastrectomy specimen could be compared in 16 surgical patients. There was a significant correlation between the integrated gastrin response to feeding and the total gastrin cell number in the stomach. No correlation was found between the basal serum gastrin level and the total gastrin cell count. A total gastrin cell number higher than 50 million was found in the stomach of three duodenal ulcer patients with preoperative postprandial hypergastrinemia as well as in one patient with normal serum gastrin values. Gastrin cell counts between 6 and 42 million were found in control stomachs and in patients with gastric ulcer. Preoperative feeding tests could be useful to select patients with an elevated antral G cell number.
采用组织学计数法和面积测量法，对溃疡患者和非溃疡患者胃内胃泌素（G）细胞的总数进行了测定。对16例手术患者术前基础和餐后血清胃泌素值以及胃切除标本中的胃泌素细胞量进行了比较。进食后胃泌素的综合反应与胃内胃泌素细胞总数之间存在显著相关性。基础血清胃泌素水平与胃泌素细胞总数之间未发现相关性。在3例术前餐后高胃泌素血症的十二指肠溃疡患者以及1例血清胃泌素值正常的患者胃内，发现胃泌素细胞总数高于5000万。在对照胃组织以及胃溃疡患者胃内，发现胃泌素细胞计数在600万至4200万之间。术前进食试验可能有助于筛选胃窦G细胞数量增加的患者。
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