Xiong Wei, Zeng Zhao-Yang, Li Xiao-Ling, Li Wei-Fang, Li Jiang, He Lin, Li Gui-Yuan
Cancer Research Institute, Xiangya Medical School of Central South University, Changsha 410078, China.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Jul;34(4):512-5.
Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in southern China. Recently, a NGX6 gene was cloned, which is located in the region of minimal heterozygosity deletion at 9p21.3-22.1 and is down-expressed in NPC. The latest results suggest that the NGX6 gene is a candidate tumor suppressor for NPC. A correlation study using 2 single-nucleotide polymorphisms (SNPs) within NGX6 gene by means of dynamic allele specific hybridization (DASH) was performed in 105 unrelated case subjects and 183 control subjects which matched to the NPC cases in age, sex and residence. Significant results were obtained for one SNP mark (rs879284), which was located at -237 bp 5' up-stream of NGX6 gene, and the relative risk of this SNP mark was 3.93 (genotype CT) and 2.27 (genotype TT). The result has proved again that NGX6 gene may play a certain role in oncogenesis and development of nasopharyngeal carcinoma. The SNP mark rs879284 may influence on the expression of NGX6 gene due to its location on chromosome.
鼻咽癌（NPC）在世界上大多数地区都很罕见，但在中国南方却很普遍。最近，一个NGX6基因被克隆出来，它位于9p21.3 - 22.1的最小杂合性缺失区域，并且在鼻咽癌中表达下调。最新结果表明，NGX6基因是鼻咽癌的一个候选抑癌基因。通过动态等位基因特异性杂交（DASH）对105名无亲缘关系的病例受试者和183名在年龄、性别和居住地与鼻咽癌病例相匹配的对照受试者进行了一项关于NGX6基因内2个单核苷酸多态性（SNP）的相关性研究。在位于NGX6基因5'上游 - 237 bp处的一个SNP标记（rs879284）上获得了显著结果，该SNP标记的相对风险为3.93（基因型CT）和2.27（基因型TT）。该结果再次证明NGX6基因可能在鼻咽癌的发生和发展中起一定作用。SNP标记rs879284因其在染色体上的位置可能影响NGX6基因的表达。
