He Shiwei, Zhong Yancheng, Shuai Cijun, Gao Dan, Wei Pingpin, Li Guiyuan, Peng Shuping
Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.
Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, China.
Tumour Biol. 2016 May;37(5):5751-60. doi: 10.1007/s13277-016-4966-5. Epub 2016 Feb 15.
Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a membrane protein primarily located in the nuclear membrane and cell membrane. Several groups reported that NGX6 gene was down-regulated in nasopharyngeal carcinoma (NPC), gastric cancer, lung cancer, liver cancer, and colorectal cancer and even less in the carcinomas with metastasis. Current studies have demonstrated that NGX6 possesses various biological functions, such as regulating protein expression of related genes, involving cell signal transduction pathways, negatively controlling cell cycle progression, inhibiting angiogenesis, and increasing the sensitivity of patients to anti-cancer drugs. Some factors regulating the expression level of NGX6 gene also have been studied. The methylation of promoter of NGX6 and histone H3K9 negatively regulates its expression, similar to the function of transcription factor special protein-1 (Sp1). However, the regulatory factor early growth response gene 1 (Egr-1) is provided with positive regulation function. This review will summarize the progress of those studies on NGX6 and elucidate the potential application of NGX6 for some malignant diseases.
鼻咽癌相关基因6（NGX6）是一种主要位于核膜和细胞膜的膜蛋白。多个研究小组报道，NGX6基因在鼻咽癌（NPC）、胃癌、肺癌、肝癌和结直肠癌中表达下调，在伴有转移的癌症中表达下调更为明显。目前的研究表明，NGX6具有多种生物学功能，如调节相关基因的蛋白表达、参与细胞信号转导通路、负向调控细胞周期进程、抑制血管生成以及增加患者对抗癌药物的敏感性。一些调节NGX6基因表达水平的因素也已得到研究。NGX6启动子和组蛋白H3K9的甲基化对其表达具有负向调节作用，类似于转录因子特异性蛋白-1（Sp1）的功能。然而，早期生长反应基因1（Egr-1）具有正向调节功能。本综述将总结这些关于NGX6的研究进展，并阐明NGX6在某些恶性疾病中的潜在应用。
