生育酚可增强成年大鼠齿状回中的神经发生。

Tocopherols enhance neurogenesis in dentate gyrus of adult rats.

作者信息

Cuppini Riccardo, Ciaroni Sandra, Cecchini Tiziana, Ambrogini Patrizia, Ferri Paola, Cuppini Carla, Ninfali Paolino, Del Grande Paolo

机构信息

Institute of Physiological Sciences, University of Urbino, Crocicchia, I-61029 Urbino, Italy.

出版信息

Int J Vitam Nutr Res. 2002 May;72(3):170-6. doi: 10.1024/0300-9831.72.3.170.

DOI:10.1024/0300-9831.72.3.170

PMID:12098885

Abstract

In the dentate gyrus of the mammalian hippocampus, neurogenesis carries on throughout postnatal life. The aim of this work was to identify an exogenous control factor of adult neurogenesis. Neurogenesis in the adult dentate gyrus was previously found to be enhanced in vitamin E-deficient rats. The effects of alpha- or beta-tocopherol supplementation on neurogenesis in the adult dentate gyrus were investigated by 5-bromo-2'-deoxyuridine labeling. Tocopherol was found to increase the survival of newborn cells and the total number of granule cells in the adult rat dentate gyrus. Newborn cells were phenotypically characterized by expression of the immature neuron marker TOAD-64 (turned on after division-64). Therefore tocopherol in high doses possibly increases the number of granule cells in the dentate gyrus by saving newborn cells from death.

摘要

在哺乳动物海马体的齿状回中，神经发生在出生后的整个生命过程中持续进行。这项工作的目的是确定成年神经发生的外源性控制因素。此前发现，维生素E缺乏的大鼠成年齿状回中的神经发生会增强。通过5-溴-2'-脱氧尿苷标记研究了补充α-生育酚或β-生育酚对成年齿状回神经发生的影响。发现生育酚可提高成年大鼠齿状回中新生细胞的存活率和颗粒细胞的总数。新生细胞通过未成熟神经元标志物TOAD-64（分裂后开启-64）的表达进行表型特征分析。因此，高剂量的生育酚可能通过挽救新生细胞免于死亡来增加齿状回中颗粒细胞的数量。