完全缓解的成年急性白血病患者无关脐血移植与无关骨髓移植的临床比较

A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission.

作者信息

Ooi Jun, Iseki Tohru, Takahashi Satoshi, Tomonari Akira, Nagayama Hitomi, Ishii Koji, Ito Kiyoshi, Sato Hiroyuki, Takahashi Tsutomu, Shindo Motohiro, Sekine Rieko, Ohno Nobuhiro, Uchimaru Kaoru, Nagamura Fumitaka, Shirafuji Naoki, Tojo Arinobu, Tani Kenzaburo, Asano Shigetaka

机构信息

Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

出版信息

Br J Haematol. 2002 Jul;118(1):140-3. doi: 10.1046/j.1365-2141.2002.03650.x.

DOI:10.1046/j.1365-2141.2002.03650.x

PMID:12100139

Abstract

We performed a clinical comparison of unrelated cord blood transplantation (UCBT) and unrelated bone marrow transplantation in adult acute leukaemia patients in complete remission (CR) who received the same conditioning regimen, graft-versus-host disease (GvHD) prophylaxis and supportive treatment. The incidence of acute GvHD was almost the same between the two groups, but the haematopoietic recovery was delayed and the incidence of chronic GvHD was higher in the UCBT group. The probability of 2 year disease-free survival was similar between the two groups. These results suggest that adult acute leukaemia patients in CR without a suitable donor should be considered as candidates for UCBT.

摘要

我们对处于完全缓解（CR）期的成年急性白血病患者进行了非亲缘脐血移植（UCBT）与非亲缘骨髓移植的临床比较，这些患者接受相同的预处理方案、移植物抗宿主病（GvHD）预防措施及支持治疗。两组急性GvHD的发生率几乎相同，但脐血移植组造血恢复延迟且慢性GvHD的发生率更高。两组的2年无病生存率相似。这些结果表明，对于没有合适供体的CR期成年急性白血病患者，应考虑将其作为脐血移植的候选对象。