Eiling S, Lischner S, Busch J-O, Rothaupt D, Christophers E, Hauschild A
Department of Dermatology, University of Kiel, Schittenhelmstrasse 7, Germany.
Br J Dermatol. 2002 Jul;147(1):150-3. doi: 10.1046/j.1365-2133.2002.04726.x.
We report an 80-year-old man suffering from an angiosarcoma of the scalp. Because of the wide extent of the lesions, surgery was not performed. Instead, the patient was treated with electron-beam radiation. Later, the patient failed to benefit from radiotherapy demonstrated by a local relapse and new malignant lesions. Additionally, a cervical lymph node metastasis appeared for the first time. Subsequently, we successfully administered liposomal doxorubicin (Caelyx(R)). Shortly after administration of two cycles the scalp angiosarcoma showed a clear regression. Following six cycles, the patient clinically showed a complete remission of all skin lesions and the cervical lymph node; metastasis was confirmed by histology and fine needle aspiration, respectively. Liposomal and pegylated doxorubicin, a cytostatic drug belonging to the anthracyclines, has already shown to be effective and mostly well tolerated in the therapy of acquired immune deficiency syndrome-related Kaposi's sarcoma and very recently in cutaneous T-cell lymphoma, too. Caelyx(R) appears to be a promising alternative to conventional treatment of cutaneous angiosarcoma.
我们报告了一名80岁患有头皮血管肉瘤的男性患者。由于病变范围广泛，未进行手术。取而代之的是，该患者接受了电子束放疗。后来，患者未能从放疗中获益，出现了局部复发和新的恶性病变。此外，首次出现了颈部淋巴结转移。随后，我们成功给予了脂质体阿霉素（楷莱®）。在给予两个周期后不久，头皮血管肉瘤明显消退。六个周期后，患者临床上所有皮肤病变和颈部淋巴结均完全缓解；分别通过组织学和细针穿刺证实转移灶已消失。脂质体和聚乙二醇化阿霉素是一种属于蒽环类的细胞毒性药物，已显示在获得性免疫缺陷综合征相关的卡波西肉瘤治疗中有效且大多耐受性良好，最近在皮肤T细胞淋巴瘤治疗中也有效。楷莱®似乎是皮肤血管肉瘤传统治疗的一种有前景的替代方法。
