Moore F G A, Wolfson C
Department of Nurology, McGill University, Montereal, Quebec, Canada.
Acta Neurol Scand. 2002 Aug;106(2):63-83. doi: 10.1034/j.1600-0404.2002.01251.x.
To systematically review the published evidence for a relationship between human herpes virus 6 (HHV-6) and multiple sclerosis (MS).
The medical literature was searched using MEDLINE and the Cochrane database. Retrieved studies are presented according to the experimental technique(s) used. The studies are rated for quality using a priori defined criteria.
Twenty-eight studies were retrieved. A total of 12 different experimental techniques were used. Four of these techniques provided evidence for a relationship between HHV-6 and MS, but none were able to show a causative relationship.
The available literature provides some support for a relationship between HHV-6 and MS. The limitations of the available studies and directions for future research are discussed.
系统回顾已发表的关于人类疱疹病毒6型（HHV - 6）与多发性硬化症（MS）之间关系的证据。
使用MEDLINE和Cochrane数据库检索医学文献。检索到的研究根据所使用的实验技术进行呈现。使用预先定义的标准对研究质量进行评分。
检索到28项研究。总共使用了12种不同的实验技术。其中四种技术提供了HHV - 6与MS之间存在关联的证据，但均未能表明存在因果关系。
现有文献为HHV - 6与MS之间的关系提供了一些支持。讨论了现有研究的局限性以及未来研究的方向。
