2nd Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
BMC Neurol. 2022 Feb 15;22(1):57. doi: 10.1186/s12883-022-02568-7.
This is an update on the existing evidence regarding a relationship between infection with human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) in order to contribute on the attempt to define the nature and strength of that relationship.
Study quality was assessed using the criteria proposed by Moore and Wolfson and by the classification criteria used by the Canadian Task Force on the Periodic Health Examination. Studies were categorized both by experimental technique and by quality (high [A], intermediate [B], and low [C]) as determined by the Moore and Wolfson criteria. Overall, 27 (90%) of 30 studies, 18 (86%) of which were classified as A quality, reached a statistically significant result. According to the Canadian Task Force classification, all studies were categorized as evidence of qualityII-1. Limitations of the available experimental techniques and perspectives for future research are discussed.
The current review continues to emphasize the need for further, objective, evidence-based examination of the relationship between HHV-6 infection and multiple sclerosis.
这是对人疱疹病毒 6（HHV-6）感染与多发性硬化症（MS）之间关系的现有证据的更新，旨在帮助确定这种关系的性质和强度。
使用 Moore 和 Wolfson 提出的标准以及加拿大定期健康检查工作队使用的分类标准评估了研究质量。根据 Moore 和 Wolfson 标准，研究分为实验技术和质量（高[ A ]、中[ B ]和低[ C ]）。总体而言，30 项研究中的 27 项（90%），其中 18 项（86%）质量评为 A，达到了统计学上的显著结果。根据加拿大工作队的分类，所有研究均归类为证据质量 II-1。讨论了现有实验技术的局限性和未来研究的展望。
目前的综述继续强调需要进一步进行客观的、基于证据的研究，以检验 HHV-6 感染与多发性硬化症之间的关系。
