细胞凋亡与免疫中的“纸牌游戏”
CARD games in apoptosis and immunity.
作者信息
Bouchier-Hayes Lisa, Martin Seamus J
机构信息
Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland.
出版信息
EMBO Rep. 2002 Jul;3(7):616-21. doi: 10.1093/embo-reports/kvf139.
Abstract
A bewildering array of proteins containing the caspase recruitment domain (CARD) have now been identified. Previously, CARD-CARD interactions have been shown to be involved in the assembly of protein complexes that promote caspase processing and activation in the context of apoptosis. However, as the family of CARD-containing proteins has grown, it has become apparent that the majority of these proteins do not recruit caspases or promote caspase activation. Instead, many participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Here, we suggest a simplified classification of the CARD proteins based upon their domain structures and discuss the divergent roles of these proteins in the context of host defence.
摘要
目前已鉴定出一系列令人眼花缭乱的含有半胱天冬酶招募结构域（CARD）的蛋白质。以前，CARD-CARD相互作用已被证明参与了在细胞凋亡过程中促进半胱天冬酶加工和激活的蛋白质复合物的组装。然而，随着含CARD蛋白质家族的不断扩大，很明显这些蛋白质中的大多数并不招募半胱天冬酶或促进半胱天冬酶激活。相反，许多蛋白质参与了与先天或适应性免疫反应相关的核因子κB信号通路。在此，我们基于其结构域结构对CARD蛋白质提出一种简化分类，并讨论这些蛋白质在宿主防御中的不同作用。
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