Kosiakov K S
Vopr Neirokhir. 1975 Nov-Dec(6):41-4.
Proceeding from the current ideas on the significance of the catalase in the oxidative phosphorylation, oxygenation and desoxygenation of hemoglobin the activity of the above enzyme was studied in the blood of 60 patients with brain tumours. It was found that prior to a surgical intervention the catalase activity at the rate per 1 g of hemoglobin (the catalase index-CI) varied within the same range in patients with brain tumours of a different histological structure (meningiomas, adenomas of the pituitary, gliomas, metastases of cancer). The catalase index of the patients' blood does not differ from that in healthy individuals. In the post-operative period the catalase index rises right from the first days, paralleling the development of a general reaction to the damage. There exists a correlation between a fall in the level of hemoglobin and a rise of the catalase index, which apparently, has a compensatory significance. An investigation of the catalase in the clinical picture of the stress-syndrome may be of use for prognostic purposes.
基于目前关于过氧化氢酶在氧化磷酸化、血红蛋白的氧合和脱氧过程中的重要性的观点，对60例脑肿瘤患者血液中上述酶的活性进行了研究。结果发现，在手术干预前，不同组织学结构（脑膜瘤、垂体腺瘤、胶质瘤、癌转移瘤）的脑肿瘤患者每1克血红蛋白的过氧化氢酶活性（过氧化氢酶指数-CI）在相同范围内变化。患者血液中的过氧化氢酶指数与健康个体无差异。在术后阶段，过氧化氢酶指数从术后第一天就开始升高，与对损伤的全身反应的发展平行。血红蛋白水平的下降与过氧化氢酶指数的升高之间存在相关性，这显然具有代偿意义。研究应激综合征临床表现中的过氧化氢酶可能对预后有帮助。
