Kastrikina L N, Kopylova N V, Rybakova E P, Ladodo K S, Churdaleva E V, Spirichev V B
Vopr Pitan. 1975 Sep-Oct(5):12-8.
Subjects of discussion in the paper are various methods of determining the riboflavin allowances and the results achieved by the application of two of them that concern determining the activity of the glutathione-reductase and the FAD-effect in the study of an experimental B2-deficiency in rats and the riboflavin allowances in children suffering from phenylketonuria. Exclusion of vitamin B2 from the ration of rats resulted in that in 8 weeks they developed B2-deficiency ascertained with the help of the above cited enzymatic tests. In a certain percentage of children with phenylketonuria after discontinued administration of group "B" vitamins (D1 diet) there could be observed an intensification of the FAD-effect and, accordingly, a reduced glutathione-reductase activity. Resumed taking of the vitamins (D2 diet) normalized the riboflavin allowance values in at least, one week's time.
本文讨论的主题是确定核黄素摄入量的各种方法，以及应用其中两种方法所取得的结果，这两种方法涉及在大鼠实验性维生素B2缺乏症研究中测定谷胱甘肽还原酶的活性和黄素腺嘌呤二核苷酸（FAD）效应，以及苯丙酮尿症患儿的核黄素摄入量。从大鼠日粮中排除维生素B2导致在8周内它们出现了通过上述酶促试验确定的维生素B2缺乏症。在一定比例的苯丙酮尿症患儿中，停用“B”族维生素（D1饮食）后，可观察到FAD效应增强，相应地，谷胱甘肽还原酶活性降低。重新摄入维生素（D2饮食）至少在一周时间内使核黄素摄入量值恢复正常。
