Kovalenko T A, Kodentsova V M, Sokol'nikov A A, Iakushina L M, Kharitonchik L A, Sonin B V, Stroev E A
Probl Tuberk. 1993(6):42-5.
It was established that 10-day administration of suppository methazide (20 mg per 100 g b. w.) induces B2 vitamin deficiency indicated by relevant hepatic and plasmic values. In vitamin B2 deficiency methazide-induced changes in vitamin B6 metabolism are less marked in rats provided with riboflavin. Use of suppository methazide in combination with riboflavin (100 micrograms per animal which is a recommended daily dose) prevents B2 deficiency. It is recommended daily use combinations of methazide with riboflavin or piridoxin in essential daily consumption doses to treat patients with alimentary vitamin B2 and B6 deficiencies. This will not only prevent side effects of methazide, but also help to overcome deficiency of the above vitamins.
已确定，连续10天给予栓剂美他嗪（每100克体重20毫克）会导致B2维生素缺乏，这可通过相关的肝脏和血浆值来表明。在维生素B2缺乏的情况下，美他嗪诱导的维生素B6代谢变化在补充核黄素的大鼠中不太明显。将栓剂美他嗪与核黄素（每只动物100微克，这是推荐的每日剂量）联合使用可预防B2缺乏。建议每日使用美他嗪与核黄素或吡哆醇按基本每日消费剂量的组合，以治疗患有营养性维生素B2和B6缺乏症的患者。这不仅可以预防美他嗪的副作用，还有助于克服上述维生素的缺乏。
