Grune T
Neuroscience Research Center, Medical Faculty (Charité), Humboldt University Berlin, Germany.
Hum Exp Toxicol. 2002 Feb;21(2):61-2. doi: 10.1191/0960327102ht210oa.
The role of oxygen free radicals and other oxidants in several diseases has been well established over the past decade. Whereas it was long known that high doses of oxidants may damage or kill cells, the effect of low doses or long-time exposure to small flux rates of oxidants have been the focus of the free radical research until now. Here one has to take into account that most physiological and pathophysiological actions of oxidants and free radicals are based on the permanent action of small doses and flux rates. This includes effects of oxidants on signal transduction pathways and gene expression patterns. Therefore, only a few answers can be given today on the relevance of the effects of low doses of oxidants.
在过去十年中，氧自由基和其他氧化剂在多种疾病中的作用已得到充分证实。长期以来人们都知道高剂量的氧化剂可能会损伤或杀死细胞，而低剂量或长时间暴露于低通量的氧化剂的影响一直是自由基研究至今的焦点。在此必须考虑到，氧化剂和自由基的大多数生理和病理生理作用都基于小剂量和通量率的持续作用。这包括氧化剂对信号转导通路和基因表达模式的影响。因此，如今对于低剂量氧化剂作用的相关性只能给出少数答案。
