致癌作用中的氧化应激信号传导：一篇评论

Oxidant signalling in carcinogenesis: a commentary.

作者信息

Deshpande S S, Irani K

机构信息

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

出版信息

Hum Exp Toxicol. 2002 Feb;21(2):63-4. doi: 10.1191/0960327102ht211oa.

DOI:10.1191/0960327102ht211oa

PMID:12102497

Abstract

It is becoming increasingly evident that reactive oxygen species (ROS) act at different stages of carcinogenesis, and thus play multiple roles in oncogenesis. In addition to being mutagenic and initiating tumors, ROS or carcinogens that result in ROS generation may affect tumor promotion and progression through varied effects on growth promoting, growth inhibitory, or apoptotic signaling pathways.

摘要

越来越明显的是，活性氧（ROS）在致癌作用的不同阶段发挥作用，因此在肿瘤发生过程中扮演多种角色。除了具有致突变性和引发肿瘤外，ROS或导致ROS产生的致癌物可能通过对生长促进、生长抑制或凋亡信号通路产生不同影响，进而影响肿瘤的促进和进展。