高血压状态下心血管功能状态的模拟研究

Simulation study of the cardiovascular functional status in hypertensive situation.

作者信息

Li Xinsheng, Bai Jing, Cui Shuqi, Wang Shuzhong

机构信息

Department of Electrical Engineering, Institute of Biomedical Engineering, Tsinghua University, Beijing 100084, China.

出版信息

Comput Biol Med. 2002 Sep;32(5):345-62. doi: 10.1016/s0010-4825(02)00020-3.

DOI:10.1016/s0010-4825(02)00020-3

PMID:12102753

Abstract

An extended cardiovascular model was established based on our previous work to study the consequences of physiological or pathological changes to the homeostatic functions of the cardiovascular system. To study hemodynamic changes in hypertensive situations, the impacts of cardiovascular parameter variations (peripheral vascular resistance, arterial vessel wall stiffness and baroreflex gain) upon hemodynamics and the short-term regulation of the cardiovascular system were investigated. For the purpose of analyzing baroregulation function, the short-term regulation of arterial pressure in response to moderate dynamic exercise for normotensive and hypertensive cases was studied through computer simulation and clinical experiments. The simulation results agree well with clinical data. The results of this work suggest that the model presented in this paper provides a useful tool to investigate the functional status of cardiovascular system in normal or pathological conditions.

摘要

基于我们之前的工作建立了一个扩展的心血管模型，以研究生理或病理变化对心血管系统稳态功能的影响。为了研究高血压情况下的血流动力学变化，研究了心血管参数变化（外周血管阻力、动脉血管壁硬度和压力反射增益）对血流动力学和心血管系统短期调节的影响。为了分析压力调节功能，通过计算机模拟和临床实验研究了正常血压和高血压病例在中等强度动态运动时动脉血压的短期调节。模拟结果与临床数据吻合良好。这项工作的结果表明，本文提出的模型为研究正常或病理条件下心血管系统的功能状态提供了一个有用的工具。