Burns R S, Lerner S E, Corrado R, James S H, Schnoll S H
West J Med. 1975 Nov;123(5):345-9.
Phencyclidine is now one of the most frequently used main ingredients of "street drug" preparations. Its effects are highly dose dependent and three varieties of acute intoxication have been seen clinically associated with different dosages and routes of administration. Most persons using phencyclidine smoke it sprinkled on parsley in low doses. The presence of horizontal and vertical nystagmus associated with hypertension in a patient who is agitated or comatose are diagnostic of a phencyclidine intoxicated state. Sensory isolation and intravenous administration of diazepam in the event of seizure activity have proved effective in the treatment of acute intoxicated states. Phencyclidine has pronounced behavioral toxicity and several deaths due to this agent have now been documented. It is unknown whether seizure activity or respiratory depression is the primary cause of death in pharmacological overdoses.
苯环利定现在是“街头毒品”制剂中最常用的主要成分之一。其作用高度依赖剂量，临床上已观察到三种急性中毒情况，与不同剂量和给药途径相关。大多数使用苯环利定的人会低剂量地将其撒在欧芹上吸食。躁动或昏迷患者出现与高血压相关的水平和垂直眼球震颤可诊断为苯环利定中毒状态。在癫痫发作时进行感觉隔离和静脉注射地西泮已被证明对治疗急性中毒状态有效。苯环利定有明显的行为毒性，现已记录到几起因该药物导致的死亡案例。在药物过量中毒时，癫痫发作或呼吸抑制是否是主要死因尚不清楚。
