Chaplygina S R
Zh Vyssh Nerv Deiat Im I P Pavlova. 1975 Jan-Feb;25(1):66-9.
In experiments on mice of the BALB/c strain a study was made of the influence of lysergic acid diethylamide (LSD) on the retention and reproduction of a conditioned passive avoidance reaction (CPAR). A 0.5-3.0 mg/kg of LSD Injected intraperitoneally 10 min. before the learning procedure, worsened the CPAR retention, while a 0.2 mg/kg of LSD Improved it. The drug (0.2 mg/kg) facilitated the retrieval of the reaction, which did not manifest itself in 24 and 48 hours after learning. This effect depended on the strength of the unconditioned stimulus presented during learning as well as on the time intervals between the moments of learning and testing. Facilitated CPAR retrieval was observed only during the action of the drug and disappeared in 24 hours after its administration. The possible physiological mechanisms of LSD influence on memory processes are discussed.
在对BALB/c品系小鼠进行的实验中，研究了麦角酸二乙酰胺（LSD）对条件性被动回避反应（CPAR）的保持和再现的影响。在学习程序前10分钟腹腔注射0.5 - 3.0毫克/千克的LSD会使CPAR的保持变差，而0.2毫克/千克的LSD则会改善CPAR的保持。该药物（0.2毫克/千克）促进了反应的恢复，这在学习后24小时和48小时并未表现出来。这种效应取决于学习过程中呈现的非条件刺激的强度以及学习和测试时刻之间的时间间隔。仅在药物作用期间观察到CPAR恢复得到促进，且在给药后24小时消失。文中讨论了LSD影响记忆过程的可能生理机制。
