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1
Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis.枯草芽孢杆菌功能基因组学：通过蛋白质组和转录组分析对严谨反应进行全面表征。
J Bacteriol. 2002 May;184(9):2500-20. doi: 10.1128/JB.184.9.2500-2520.2002.
2
Prediction of gene function in methylthioadenosine recycling from regulatory signals.从调控信号预测甲硫腺苷循环中的基因功能。
J Bacteriol. 2002 Apr;184(8):2314-8. doi: 10.1128/JB.184.8.2314-2318.2002.
3
Posttranscription initiation control of tryptophan metabolism in Bacillus subtilis by the trp RNA-binding attenuation protein (TRAP), anti-TRAP, and RNA structure.枯草芽孢杆菌中色氨酸代谢的转录起始后调控：由色氨酸RNA结合衰减蛋白（TRAP）、抗TRAP及RNA结构介导
J Bacteriol. 2001 Oct;183(20):5795-802. doi: 10.1128/JB.183.20.5795-5802.2001.
4
A comprehensive two-dimensional map of cytosolic proteins of Bacillus subtilis.枯草芽孢杆菌胞质蛋白的全面二维图谱。
Electrophoresis. 2001 Aug;22(14):2908-35. doi: 10.1002/1522-2683(200108)22:14<2908::AID-ELPS2908>3.0.CO;2-M.
5
Extracting biological information from DNA arrays: an unexpected link between arginine and methionine metabolism in Bacillus subtilis.从DNA阵列中提取生物学信息：枯草芽孢杆菌中精氨酸和甲硫氨酸代谢之间的意外联系。
Genome Biol. 2001;2(6):RESEARCH0019. doi: 10.1186/gb-2001-2-6-research0019. Epub 2001 Jun 1.
6
Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels.枯草芽孢杆菌CodY通过感知鸟苷三磷酸（GTP）水平来抑制早期稳定期基因。
Genes Dev. 2001 May 1;15(9):1093-103. doi: 10.1101/gad.874201.
7
Conservation of the binding site for the arginine repressor in all bacterial lineages.所有细菌谱系中精氨酸阻遏物结合位点的保守性。
Genome Biol. 2001;2(4):RESEARCH0013. doi: 10.1186/gb-2001-2-4-research0013. Epub 2001 Mar 22.
8
The stringent response, sigmaH-dependent gene expression and sporulation in Bacillus subtilis.枯草芽孢杆菌中的严谨反应、σH 依赖性基因表达及芽孢形成
Mol Gen Genet. 2001 Feb;264(6):913-23. doi: 10.1007/s004380000381.
9
Regulation of sigma factor activity during Bacillus subtilis development.枯草芽孢杆菌发育过程中σ因子活性的调控。
Curr Opin Microbiol. 2000 Dec;3(6):553-60. doi: 10.1016/s1369-5274(00)00140-5.
10
Transcriptional control of the sulfur-regulated cysH operon, containing genes involved in L-cysteine biosynthesis in Bacillus subtilis.枯草芽孢杆菌中硫调节的cysH操纵子的转录调控，该操纵子包含参与L-半胱氨酸生物合成的基因。
J Bacteriol. 2000 Oct;182(20):5885-92. doi: 10.1128/JB.182.20.5885-5892.2000.

枯草芽孢杆菌基因表达受氨基酸可用性调控的转录组和蛋白质组分析

Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.

作者信息

Mäder Ulrike, Homuth Georg, Scharf Christian, Büttner Knut, Bode Rüdiger, Hecker Michael

机构信息

Institut für Mikrobiologie, Ernst-Moritz-Arndt-Universität Greifswald, D-17487 Greifswald, Germany.

出版信息

J Bacteriol. 2002 Aug;184(15):4288-95. doi: 10.1128/JB.184.15.4288-4295.2002.

DOI:10.1128/JB.184.15.4288-4295.2002
PMID:12107147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC135197/
Abstract

A comprehensive study of Bacillus subtilis gene expression patterns in response to amino acid availability was performed by means of proteomics and transcriptomics. The methods of two-dimensional protein gel electrophoresis and DNA macroarray technology were combined to analyze cells exponentially grown in minimal medium with and without 0.2% Casamino Acids (CAA). This approach revealed about 120 genes predominantly involved in amino acid biosynthesis, sporulation, and competence, which were downregulated in CAA-containing medium. Determination of sporulation frequencies confirmed the physiological relevance of the expression data.

摘要

通过蛋白质组学和转录组学方法，对枯草芽孢杆菌在氨基酸可利用情况下的基因表达模式进行了全面研究。将二维蛋白质凝胶电泳和DNA微阵列技术相结合，分析了在添加和不添加0.2%酪蛋白氨基酸（CAA）的基本培养基中指数生长的细胞。该方法揭示了约120个主要参与氨基酸生物合成、芽孢形成和感受态的基因，它们在含CAA的培养基中表达下调。芽孢形成频率的测定证实了表达数据的生理相关性。