Hosoe Hisashi, Kaise Toshihiko, Ohmori Kenji
Pharmaceutical Research & Development Center, Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan.
Arzneimittelforschung. 2002;52(6):435-40. doi: 10.1055/s-0031-1299911.
Erdosteine (CAS 84611-23-4) and its active metabolite (M1) decrease the luminol-dependent chemiluminescence (LDCL). In this study, the scavenging effects of erdosteine and M1 on each reactive oxygen species, hypochlorous acid (HOCl), hydrogen peroxide (H2O2) and superoxide anion (O2-), were investigated. M1 interacted with HOCl at high activity, whereas erdosteine exhibited low activity. Although erdosteine interacted with H2O2 only at 1 mmol/l, M1 could significantly decrease H2O2 (> 0.1 mmol/l). Erdosteine and M1 did not interact with O2-. These results suggest that M1 possesses scavenging activities against H2O2 and HOCl in vitro.
厄多司坦（CAS 84611-23-4）及其活性代谢物（M1）可降低鲁米诺依赖性化学发光（LDCL）。在本研究中，研究了厄多司坦和M1对每种活性氧、次氯酸（HOCl）、过氧化氢（H2O2）和超氧阴离子（O2-）的清除作用。M1与HOCl以高活性相互作用，而厄多司坦表现出低活性。尽管厄多司坦仅在1 mmol/l时与H2O2相互作用，但M1可显著降低H2O2（>0.1 mmol/l）。厄多司坦和M1不与O2-相互作用。这些结果表明，M1在体外具有对H2O2和HOCl的清除活性。
