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对抗新冠病毒中的反应性硫化合物

Reactive Sulfur Compounds in the Fight against COVID-19.

作者信息

Iciek Małgorzata, Bilska-Wilkosz Anna, Kozdrowicki Michał, Górny Magdalena

机构信息

Chair of Medical Biochemistry, Medical College, Jagiellonian University, 31-034 Kraków, Poland.

出版信息

Antioxidants (Basel). 2022 May 26;11(6):1053. doi: 10.3390/antiox11061053.

DOI:10.3390/antiox11061053
PMID:35739949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9220020/
Abstract

The SARS-CoV-2 coronavirus pandemic outbreak in 2019 resulted in the need to search for an effective and safe strategy for treating infected patients, relieving symptoms, and preventing severe disease. SARS-CoV-2 is an RNA virus that can cause acute respiratory failure and thrombosis, as well as impair circulatory system function. Permanent damage to the heart muscle or other cardiovascular disorders may occur during or after the infection. The severe course of the disease is associated with the release of large amounts of pro-inflammatory cytokines. Due to their documented anti-inflammatory, antioxidant, and antiviral effects, reactive sulfur compounds, including hydrogen sulfide (HS), lipoic acid (LA), N-acetylcysteine (NAC), glutathione (GSH), and some other lesser-known sulfur compounds, have attracted the interest of scientists for the treatment and prevention of the adverse effects of diseases caused by SARS-CoV-2. This article reviews current knowledge about various endogenous or exogenous reactive sulfur compounds and discusses the possibility, or in some cases the results, of their use in the treatment or prophylaxis of COVID-19.

摘要

2019年新型冠状病毒肺炎疫情的爆发，使得人们需要寻找一种有效且安全的策略来治疗感染患者、缓解症状并预防重症疾病。新型冠状病毒是一种RNA病毒，可导致急性呼吸衰竭和血栓形成，还会损害循环系统功能。感染期间或之后可能会出现心肌永久性损伤或其他心血管疾病。该疾病的严重病程与大量促炎细胞因子的释放有关。由于其已被证实的抗炎、抗氧化和抗病毒作用，包括硫化氢（HS）、硫辛酸（LA）、N-乙酰半胱氨酸（NAC）、谷胱甘肽（GSH）以及其他一些鲜为人知的含硫化合物在内的活性硫化合物，已引起科学家们对治疗和预防新型冠状病毒所致疾病不良反应的关注。本文综述了有关各种内源性或外源性活性硫化合物的现有知识，并讨论了它们用于治疗或预防新冠肺炎的可能性，在某些情况下还讨论了其使用结果。

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