Langley J M, Squires S G, MacDonald D M, Anderson D, Peltekian K, Scott J W
Clinical Trials Research Centre-Infectious Diseases, IWK Health Centre, Halifax, Nova Scotia, Canada.
Commun Dis Public Health. 2001 Dec;4(4):288-92.
Parents of children who received blood or blood products between 1984 and 1990 were notified about the potential risk of hepatitis C virus (HCV) infection. Data were collected about knowledge, attitudes and intended behaviours to determine the acceptability of the notification process. Demographic variables that may predict responses to notification were also recorded and analysed. Recipients were sent couriered letters explaining HCV risk, and the survey questionnaire. Sera were screened for HCV antibody and reactive samples confirmed with a recombinant immunoblot assay (RIBA). Four letter recipients were RIBA positive for a prevalence of 1.1% (4/358) in the notification group. Thirty-two percent of respondents did not know their child had been transfused and 58% did not know about the potential risk of HCV infection. Although 90% (165/185) felt the notification was valuable, 65% reported emotional distress (fear, worry, anger, very depressed). Responders were similar to non-responders except for HCV testing rate (76.2% v. 59.8%, p < 0.0002). Parents of children at risk of transfusion-acquired HCV virus approved of notification programs, but experienced some emotional distress. Awareness of transfusion history or risk of HCV was not universal, indicating the need to address notification to individuals, rather than through public education campaigns alone.
1984年至1990年间接受血液或血液制品的儿童的父母被告知丙型肝炎病毒（HCV）感染的潜在风险。收集了有关知识、态度和预期行为的数据，以确定通知过程的可接受性。还记录并分析了可能预测对通知反应的人口统计学变量。向接受者发送了快递信件，解释HCV风险，并附上调查问卷。对血清进行HCV抗体筛查，反应性样本用重组免疫印迹试验（RIBA）进行确认。在通知组中，有4名信件接收者RIBA呈阳性，患病率为1.1%（4/358）。32%的受访者不知道他们的孩子接受过输血，58%的人不知道HCV感染的潜在风险。尽管90%（165/185）的人认为通知很有价值，但65%的人报告有情绪困扰（恐惧、担忧、愤怒、非常沮丧）。除了HCV检测率外，回应者与未回应者相似（76.2%对59.8%，p<0.0002）。有输血获得性HCV病毒感染风险的儿童的父母认可通知程序，但经历了一些情绪困扰。对输血史或HCV风险的知晓并不普遍，这表明需要针对个人进行通知，而不是仅通过公共教育活动。
