Cagle Henry H, Jacob Jack, Homan Chriss E, Williams James L, Christensen Carol J, McMahon Brian J
Liver Disease and Hepatitis Program, Division of Community Health, Alaska Native Tribal Health Consortium, Anchorage 99508, USA.
Arch Pediatr Adolesc Med. 2007 Feb;161(2):125-30. doi: 10.1001/archpedi.161.2.125.
To notify persons who received a blood transfusion in a neonatal intensive care unit between January 1975 and July 1992 of their risk for hepatitis C infection and to encourage them to seek hepatitis C antibody testing.
Neonatal intensive care unit, blood bank, and public access records were queried to identify current mailing addresses and persons deceased. All persons were notified by letter.
Anchorage, Alaska.
Persons who received health care in an integrated health care system, the Alaska Native Medical Center, or in the private sector. Main Exposure Transfusion in the neonatal period.
Prevalence of test results positive for the hepatitis C virus antibody and RNA and awareness of having received a blood transfusion in a neonatal intensive care unit.
Alaska Native Medical Center (n = 401) and private sector (n = 1396) persons were targeted for notification. Letters were mailed to 277 Alaska Native Medical Center (69%) and 374 private sector (27%) persons, with 151 (55%) and 65 (17%) screened for hepatitis C, respectively. Among those screened (n = 216), 7 (3%) were hepatitis C antibody positive, with 6 (<3%) also hepatitis C virus-RNA positive. Among 147 persons who responded, 75 (51%) were unaware they had received a transfusion.
Compared with the private sector, a higher proportion of persons were identified and tested from the integrated health care system and more than half of respondents were unaware of their transfusion history. It would be prudent to screen neonatal intensive care unit patients who received transfusions before July 1992 for hepatitis C virus infection.
通知在1975年1月至1992年7月期间于新生儿重症监护病房接受输血的人员其感染丙型肝炎的风险，并鼓励他们进行丙型肝炎抗体检测。
查询新生儿重症监护病房、血库和公共访问记录，以确定当前邮寄地址和已故人员。所有人员均通过信件通知。
阿拉斯加安克雷奇。
在综合医疗保健系统、阿拉斯加原住民医疗中心或私营部门接受医疗保健的人员。主要暴露新生儿期输血。
丙型肝炎病毒抗体和RNA检测结果呈阳性的患病率，以及对在新生儿重症监护病房接受输血的知晓情况。
阿拉斯加原住民医疗中心（n = 401）和私营部门（n = 1396）的人员被列为通知对象。向277名阿拉斯加原住民医疗中心人员（69%）和374名私营部门人员（27%）邮寄了信件，分别有151名（55%）和65名（17%）接受了丙型肝炎筛查。在接受筛查的人员中（n = 216），7名（3%）丙型肝炎抗体呈阳性，其中6名（<3%）丙型肝炎病毒RNA也呈阳性。在147名回复者中，75名（51%）不知道自己接受过输血。
与私营部门相比，综合医疗保健系统中被识别和检测的人员比例更高，超过一半的回复者不知道自己的输血史。对1992年7月之前接受输血的新生儿重症监护病房患者进行丙型肝炎病毒感染筛查是明智的。
