Rico H, Crespo E, Hernández E R, Seco C, Crespo R
Department of Medicine, University of Alacalá, Madrid, Spain. horacio,
J Clin Densitom. 2002 Summer;5(2):187-92. doi: 10.1385/jcd:5:2:187.
We studied the effect of boron supplement on experimental osteopenia caused by strenuous exercise in 93- d-old female Wistar rats. A control group of 15 rats was not manipulated. The exercise group of 30 rats was divided into 2 groups of 15 rats each, one that was fed a diet supplemented with 50 mg/kg of boron in the form of Na(2)B(4)O(7), and other that, did not receive a boron supplement. The length and weight were determined in the femur and fifth lumbar vertebra and the bone mineral content and density were assessed through densitometry, and trabecular bone volume, trabecular number, trabecular thickness, and trabecular separation with histomorphometry. The femur length and weight, and vertebra weight, and femur and vertebra bone mineral content and density were significantly lower and the trabecular separation was higher in the exercise group than in the others (p < 0.005 in all). The femur weight, bone mineral content and density, trabecular bone volume and trabecular thickness, were significantly higher in the exercise plus boron group (p < 0.005 to 0.0001). It was concluded that boron preserves bone mass in rats that have been exposed to intense exercise.
我们研究了硼补充剂对93日龄雌性Wistar大鼠因剧烈运动引起的实验性骨质减少的影响。15只大鼠组成的对照组未进行处理。30只大鼠的运动组分为两组，每组15只，一组喂食以Na₂B₄O₇形式补充50 mg/kg硼的饮食，另一组不补充硼。测定股骨和第五腰椎的长度和重量，并通过骨密度测定评估骨矿物质含量和密度，通过组织形态计量学评估小梁骨体积、小梁数量、小梁厚度和小梁间距。运动组的股骨长度和重量、椎骨重量以及股骨和椎骨的骨矿物质含量和密度显著低于其他组，小梁间距高于其他组（均p < 0.005）。运动加硼组的股骨重量、骨矿物质含量和密度、小梁骨体积和小梁厚度显著更高（p < 0.005至0.0001）。得出的结论是，硼能维持遭受剧烈运动的大鼠的骨量。
