Rico H, Gervas J J, Hernández E R, Seco C, Villa L F, Revilla M, Sanchez-Atrio A
Department of Medicine. Alcalá University, 28801, Madrid, Spain.
Calcif Tissue Int. 1999 Aug;65(2):139-42. doi: 10.1007/s002239900672.
The ability of alprazolam to diminish cortisol response and favor ovarian function could make it useful in the prevention of osteopenia in athletes in selected cases. A sample of 45 female Wistar rats, all 93 days old and with a mean initial weight of 267 +/- 17 g, were studied. Rats were exposed to a high-performance level of exercise and were divided into two groups-one group received an alprazolam supplement and one did not-and compared with controls to determine the effect of alprazolam on bone mass as measured by dual-energy X-ray absorptiometry (DKA). Exercise consisted of treadmill running on 5 out of 7 days during a period of 11 weeks. A steep grade treadmill inclination was used to stimulate high-intensity muscle activity. Final inclination was 17.5 degrees and treadmill speed was 45 cm/second. Upon completion of the experiment, all the rats were killed and the femur and 5th lumbar vertebra were dissected and cleaned. Length, weight, bone mineral content (BMC), and density (BMD) of the whole right femur and 5th lumbar vertebra were measured. In the exercise only group (no alprazolam), the length, weight, BMC, BMD, and femur BMC/final rat weight ratio of the femur, and the vertebral weight, vertebral BMD and BMC, and vertebral BMC/final rat weight ratio were lower than in the control and the exercise-alprazolam groups (P < 0.0167 - < 0.0001). Alprazolam preserves bone mass in rats exposed to intense exercise.
阿普唑仑降低皮质醇反应并有利于卵巢功能的能力，在某些特定情况下可能有助于预防运动员的骨质减少。研究了45只93日龄的雌性Wistar大鼠，平均初始体重为267±17克。大鼠接受高强度运动，并分为两组，一组接受阿普唑仑补充剂，一组不接受，然后与对照组比较，以确定阿普唑仑对通过双能X线吸收法（DKA）测量的骨量的影响。运动包括在11周内每周7天中的5天进行跑步机跑步。使用陡峭的跑步机坡度来刺激高强度肌肉活动。最终坡度为17.5度，跑步机速度为45厘米/秒。实验结束后，所有大鼠被处死，解剖并清理股骨和第5腰椎。测量整个右股骨和第5腰椎的长度、重量、骨矿物质含量（BMC）和密度（BMD）。在仅运动组（无阿普唑仑）中，股骨的长度、重量、BMC、BMD以及股骨BMC/最终大鼠体重比，以及椎体重量、椎体BMD和BMC以及椎体BMC/最终大鼠体重比均低于对照组和运动-阿普唑仑组（P<0.0167-<0.0001）。阿普唑仑可在接受剧烈运动的大鼠中保留骨量。
