视神经炎：趋化因子受体CXCR3及其配体
Optic neuritis: chemokine receptor CXCR3 and its ligands.
作者信息
Sørensen T L, Roed H, Sellebjerg F
机构信息
Department of Ophthalmology, University of Copenhagen, Herlev Hospital, 2720 Herlev, Denmark.
出版信息
Br J Ophthalmol. 2004 Sep;88(9):1146-8. doi: 10.1136/bjo.2003.040980.
Abstract
AIM
To study the involvement of the chemokine receptor CXCR3 and its ligands (CXCL9/Mig, CXCL10/IP-10, CXCL11/ITAC) in optic neuritis (ON).
METHODS
30 patients with ON and 10 non-inflammatory neurological disease controls were included. The patients underwent a phlebotomy, lumbar puncture, and MRI scan. CXCR3 expression was studied on blood and cerebrospinal fluid (CSF) T cells by flow cytometry. CXCL9, CXCL10, and CXCL11 were measured in plasma and CSF by ELISA.
RESULTS
CSF concentrations of CXCL10, but not of CXCL9 and CXCL11, were significantly higher in ON patients than in controls. CSF concentrations of CXCL10 correlated with the CSF leucocyte count in ON patients, and CXCR3 expressing cells were significantly enriched in the CSF.
CONCLUSION
These data show that the CSF concentration of the CXCR3 ligand CXCL10 is selectively increased in CSF from ON patients, and CXCR3 positive cells are recruited to the subarachnoid space.
摘要
目的
研究趋化因子受体CXCR3及其配体（CXCL9/Mig、CXCL10/IP-10、CXCL11/ITAC）与视神经炎（ON）的关系。
方法
纳入30例视神经炎患者和10例非炎性神经系统疾病对照者。患者接受静脉采血、腰椎穿刺和磁共振成像扫描。采用流式细胞术研究血液和脑脊液（CSF）T细胞上CXCR3的表达。采用酶联免疫吸附测定法检测血浆和脑脊液中CXCL9、CXCL10和CXCL11的含量。
结果
视神经炎患者脑脊液中CXCL10的浓度显著高于对照组，而CXCL9和CXCL11的浓度无显著差异。视神经炎患者脑脊液中CXCL10的浓度与脑脊液白细胞计数相关，且脑脊液中表达CXCR3的细胞显著增多。
结论
这些数据表明，视神经炎患者脑脊液中CXCR3配体CXCL10的浓度选择性升高，且CXCR3阳性细胞被募集到蛛网膜下腔。
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