Martí D, Villagrasa V, Martinez-Solís I, Blanquer A, Castillo E, Royo L Moreno
Department of Phisiology, Pharmacology and Toxicology. Cardenal Herrera University, Valencia, Spain.
Phytother Res. 2005 Apr;19(4):298-302. doi: 10.1002/ptr.1569.
Histological and pharmacological assays have been carried out with methanol, hexane, dichloromethane and butanol extracts of Thymus piperella (L.) leaves. All the extracts were considered innocuo in the toxicity test. Methanol and also hexane, dichlorometane and butanol fractions, inhibited significantly the contractions induced by acetylcholine in isolated rat ileum in a concentration-dependent manner and the hexane extract was the most potent. However, the methanol extract did not modify the contractile effect of noradrenaline and histamine on isolated rat aorta and guinea-pig trachea respectively at the assayed dose (10, 100, 200 microg/mL). These results contribute to explain in part the use of this plant in folk medicine. In addition, morphological and histological structures characteristic of this species have been described for the first time.
已对百里香（Thymus piperella (L.)）叶片的甲醇、己烷、二氯甲烷和丁醇提取物进行了组织学和药理学分析。在毒性试验中，所有提取物均被认为无毒。甲醇以及己烷、二氯甲烷和丁醇馏分均以浓度依赖性方式显著抑制乙酰胆碱诱导的离体大鼠回肠收缩，其中己烷提取物的效果最为显著。然而，在所测定的剂量（10、100、200微克/毫升）下，甲醇提取物分别未改变去甲肾上腺素和组胺对离体大鼠主动脉和豚鼠气管的收缩作用。这些结果有助于部分解释该植物在民间医学中的应用。此外，首次描述了该物种的形态和组织结构特征。
