几种巴西药用植物对豚鼠离体回肠和大鼠十二指肠的松弛作用评估。
Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum.
作者信息
Emendörfer Fernanda, Emendörfer Fabiane, Bellato Fernanda, Noldin Vânia F, Niero Rivaldo, Cechinel-Filho Valdir, Cardozo Alcibia Maia
机构信息
Universidade do Vale do Itajaí, Itajaí, Santa Catarina, Brazil.
出版信息
J Pharm Pharm Sci. 2005 Mar 18;8(1):63-8.
PURPOSE
The present study aimed to evaluate the possible antispasmodic activity in vitro of methanolic extracts (ME) of six Brazilian medicinal plants.
METHODS
The extracts were evaluated on isolated guinea-pig ileum and rat duodenum preparations.
RESULTS
Rubus imperialis, Maytenus robusta, Ipomoea pes caprae and Epidendrum mosenii did not inhibit the contractile response elicited by acetylcholine on guinea-pig ileum. On the other hand, ME from Calophyllum brasiliense and Cynara scolymus exhibited significant inhibitory activity for the contractile response elicited by acetylcholine on guinea-pig ileum and on rat duodenum in a noncompetitive and concentration-dependent manner.
CONCLUSIONS
The current study suggests that, of the six medicinal plants evaluated, only the ME of Calophyllum brasiliense and Cynara scolymus show probable antispasmodic activity, confirming and justifying their use in folk medicine for the treatment of intestinal disorders.
目的
本研究旨在评估六种巴西药用植物甲醇提取物（ME）在体外的可能的解痉活性。
方法
在离体豚鼠回肠和大鼠十二指肠制剂上对提取物进行评估。
结果
帝王悬钩子、粗壮美登木、马鞍藤和莫氏树兰对乙酰胆碱引起的豚鼠回肠收缩反应无抑制作用。另一方面，巴西红厚壳和菜蓟的甲醇提取物对乙酰胆碱引起的豚鼠回肠和大鼠十二指肠收缩反应表现出显著的抑制活性，呈非竞争性和浓度依赖性。
结论
当前研究表明，在所评估的六种药用植物中，只有巴西红厚壳和菜蓟的甲醇提取物显示出可能的解痉活性，证实并说明了它们在民间医学中用于治疗肠道疾病的用途。
Zotero 插件