Korzan Jeffrey R, Gorassini Monica, Emery Derek, Taher Zaki A, Beaulieu Christian
Department of Biomedical Engineering, University of Alberta, Edmonton, Canada.
J Magn Reson Imaging. 2002 Jul;16(1):21-7. doi: 10.1002/jmri.10137.
To demonstrate the feasibility of obtaining high-quality magnetic resonance (MR) images of the human cervical spinal cord in vivo at a magnetic field strength of 3 T and to optimize the signal contrast between gray matter, white matter, and cerebrospinal fluid (CSF) on 2D gradient recalled echo (GRE) images of the cervical spinal cord.
Using a custom-built, anatomically molded radio frequency (RF) surface coil, the repetition time and flip angle of a 2D GRE sequence were systematically varied in five volunteers to assess tissue contrast in the cervical spinal cord.
The 2D GRE parameters for an optimal balance between gray-white matter and CSF-white matter contrast at 3 T were determined to be a time-to-repetition (TR) of 2000 msec and a flip angle of 45 degrees, with the constant short time-to-echo (TE) of 12 msec used in this study. Excellent tissue contrast and visualization of the internal anatomy of the spinal cord was demonstrated reproducibly in eight subjects using these optimal parameters.
This study demonstrates that imaging the cervical spinal cord and delineating internal spinal cord structures such as gray and white matter is feasible at 3 T.
证明在3T磁场强度下在体获取高质量人体颈段脊髓磁共振（MR）图像的可行性，并优化颈段脊髓二维梯度回波（GRE）图像上灰质、白质和脑脊液（CSF）之间的信号对比度。
使用定制的、符合解剖形态的射频（RF）表面线圈，在5名志愿者中系统改变二维GRE序列的重复时间和翻转角，以评估颈段脊髓的组织对比度。
本研究采用12毫秒恒定短回波时间（TE），确定在3T时实现灰质-白质与脑脊液-白质对比度最佳平衡的二维GRE参数为重复时间（TR）2000毫秒和翻转角45度。使用这些最佳参数，在8名受试者中可重复地显示出出色的组织对比度和脊髓内部解剖结构的可视化。
本研究表明，在3T下对颈段脊髓进行成像并勾勒脊髓内部结构如灰质和白质是可行的。
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