Novotny G E
J Hirnforsch. 1979;20(6):561-80.
The morphological signs of terminal degeneration are compared at the light and electron microscopic levels in the lateral geniculate nucleus of Macaca fascicularis, from 29 hours to 10 days after eye removal. A close correlation can be found between the appearance of degenerating RLP-terminals (i.e. large terminals containing round vesicles and pale mitochondria), which display marked, unorganized neurofilamentous hyperplasia, and the club-shaped structures revealed by neurofibrillary staning. The ring-shaped entities present in silver-impregnated material closely resemble annular bundles of neurofilaments located in smaller retinal terminals within the neuropil. Various non-filamentous degenerative forms of particularly small terminals are also described. It is concluded that the clubs and rings visualized by neurofibrillary stains in the lateral geniculate nucleus of the monkey do, indeed, represent synaptic structures. The implications of this conclusion are discussed, as are possible reasons that contrary conclusions have been drawn by other investigators. It is further suggested that club and ring formation of degenerating retinal afferents may be related to Y and X axons in the optic tract, respectively.
在摘除眼球后29小时至10天内，对猕猴外侧膝状核进行光镜和电镜观察，比较终末变性的形态学特征。在退化的RLP终末（即含有圆形囊泡和浅色线粒体的大终末）出现时，可发现其与神经原纤维染色显示的棒状结构之间存在密切相关性，这些退化的RLP终末表现出明显的、无组织的神经丝增生。银浸染材料中呈现的环形实体与位于神经毡内较小视网膜终末中的神经丝环形束非常相似。还描述了各种特别小的终末的非丝状退化形式。得出的结论是，在猴外侧膝状核中通过神经原纤维染色观察到的棒状和环状结构确实代表突触结构。讨论了这一结论的意义，以及其他研究者得出相反结论的可能原因。进一步表明，退化的视网膜传入纤维的棒状和环状形成可能分别与视束中的Y和X轴突有关。
