Robson J A
J Comp Neurol. 1981 Jan 20;195(3):453-76. doi: 10.1002/cne.901950306.
Retino-geniculate axons in the cat were induced to grow abnormally by cutting one optic nerve in kittens. Surviving optic tract axons that had grown into the denervated regions were then filled in the adults with horseradish peroxidase to reveal the terminal arbors of individual axons. Two types of abnormal axonal growth are described--translaminar growth and monocular segment growth. Translaminar growth is the most common and occurs between laminae in the binocular part to the nucleus. Axons giving rise to translaminar growth do not branch as they pass through the denervated regions of the nucleus. Instead, the abnormal branches originate from portions of the terminal arbor within the normal target lamina. These axons look like normal retino-geniculate axons in terms of their branching patterns, cytological features, and patterns of synaptic contacts except that parts of their terminal arbors have expanded to innervate inappropriate laminae. The distribution of translaminar branches overlaps the distribution of a restricted group of surviving large neurons that have not undergone denervation atrophy. Monocular segment growth invades the lateral pole of the nucleus directly from the optic tract. These branches arise from axons passing through or near the denervated region and appear to represent the formation of new terminal arbors. The synaptic swellings arising from these branches have cytological features like the synaptic swellings arising from translaminar branches and they form similar patterns of synaptic contacts. However, monocular segment branches degenerate more rapidly when damaged and they are not associated with surviving large neurons.
通过切断小猫的一条视神经，诱导猫的视网膜 - 膝状体轴突异常生长。然后，在成年猫中，用辣根过氧化物酶填充已长入去神经支配区域的存活视束轴突，以揭示单个轴突的终末分支。本文描述了两种异常轴突生长类型——跨层生长和单眼节段生长。跨层生长最为常见，发生在核的双眼部分的各层之间。产生跨层生长的轴突在穿过核的去神经支配区域时不分支。相反，异常分支起源于正常靶层内终末分支的部分。就其分支模式、细胞学特征和突触接触模式而言，这些轴突看起来像正常的视网膜 - 膝状体轴突，只是它们终末分支的部分已经扩展以支配不适当的层。跨层分支的分布与一组未经历去神经萎缩的存活大神经元的分布重叠。单眼节段生长直接从视束侵入核的外侧极。这些分支起源于穿过去神经支配区域或其附近的轴突，似乎代表新终末分支的形成。这些分支产生的突触肿胀具有与跨层分支产生的突触肿胀相似的细胞学特征，并且它们形成相似的突触接触模式。然而，单眼节段分支在受损时退化得更快，并且它们与存活的大神经元无关。
