Soheilian M, Bagheri A, Aletaha M
Ophthalmology Department and Eye Research Labbafinejad Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Eur J Ophthalmol. 2002 May-Jun;12(3):241-3. doi: 10.1177/112067210201200313.
To report a case presenting with dacryoadenitis as the earliest manifestation of systemic Wegener's granulomatosis (WG).
Observational case report.
A 41-year-old woman initially presented symptoms of bilateral dacryoadenitis. She subsequently developed upper and lower respiratory tract involvement, scleritis and keratitis.
Cytoplasmic antineutrophil antibody (c-ANCA) titer was positive. The lacrimal gland and lung biopsies were consistent with WG. The patient responded well to cyclophosphamide and prednisolone.
Dacryoadenitis maybe the earliestpresenting manifestation of WG andprompt immunosuppressive chemotherapy may control it preventing the limited disease from progressing to a complete form and reducing its morbidity and mortality.
报告一例以泪腺炎为系统性韦格纳肉芽肿(WG)最早表现的病例。
观察性病例报告。
一名41岁女性最初出现双侧泪腺炎症状。随后她出现了上、下呼吸道受累、巩膜炎和角膜炎。
胞浆抗中性粒细胞抗体(c-ANCA)滴度呈阳性。泪腺和肺部活检结果与WG相符。患者对环磷酰胺和泼尼松龙反应良好。
泪腺炎可能是WG最早出现的表现,及时进行免疫抑制化疗可对其进行控制,防止局限性疾病发展为完全型,并降低其发病率和死亡率。