抗中性粒细胞胞浆自身抗体（ANCA）诊断的伴巩膜角膜炎的韦格纳肉芽肿。

Wegener's granulomatosis presenting with sclerokeratitis diagnosed by antineutrophil cytoplasmic autoantibodies (ANCA).

作者信息

Florine C W, Dwyer M, Holland E J

机构信息

Department of Ophthalmology, University of Minnesota, Minneapolis.

出版信息

Surv Ophthalmol. 1993 Mar-Apr;37(5):373-6. doi: 10.1016/0039-6257(93)90067-h.

DOI:10.1016/0039-6257(93)90067-h

PMID:8484170

Abstract

A 23-year-old male presented with bilateral sclerokeratitis. He reported recent bronchitis, sinusitis, dyspnea on exertion, hemoptysis, arthralgias and myalgias. Wegener's granulomatosis was diagnosed by a positive antineutrophil cytoplasmic autoantibody (ANCA) test and a nasal and subglotic biopsy showing granulomatous inflammation. Treatment with cyclophosphamide, systemic corticosteroids and trimethoprim/sulfamethoxazole resulted in resolution of the sclerokeratitis and remission of the disease.

摘要

一名23岁男性出现双侧巩膜角膜炎。他自述近期患有支气管炎、鼻窦炎、劳力性呼吸困难、咯血、关节痛和肌痛。通过抗中性粒细胞胞浆自身抗体（ANCA）检测呈阳性以及鼻和声门下活检显示肉芽肿性炎症，诊断为韦格纳肉芽肿。使用环磷酰胺、全身性皮质类固醇和甲氧苄啶/磺胺甲恶唑治疗后，巩膜角膜炎消退，病情缓解。