Hashizume T, Yamaguchi T, Matsushita K
Yokohama Sakaekyosai Hospital, Yokohama City, Kanagawa, Japan.
Clin Rheumatol. 2002 Nov;21(6):525-7. doi: 10.1007/s100670200128.
Wegener's granulomatosis (WG) is a systemic granulomatous vasculitis that typically affects the upper airways, lungs and kidneys. Lymphadenopathy is rare in patients with WG. Here, we present the first case of WG whose initial manifestation was superficial lymphadenopathy (i.e. supraclavicular and axillary lymphadenopathy). One year after the initial presentation, a mass appeared in the lung. Biopsy specimens obtained from supraclavicular lymph nodes and lung demonstrated granulomatous vasculitis. This patient was negative for classic antineutrophil cytoplasmic antibodies (c-ANCA). Treatment with glucocorticoids, cyclophosphamide and trimethoprim-sulfamethoxazole has induced complete remission.
韦格纳肉芽肿（WG）是一种全身性肉芽肿性血管炎，通常累及上呼吸道、肺和肾脏。WG患者很少出现淋巴结病。在此，我们报告首例以浅表淋巴结病（即锁骨上和腋窝淋巴结病）为初始表现的WG病例。初次就诊一年后，肺部出现肿块。从锁骨上淋巴结和肺部获取的活检标本显示为肉芽肿性血管炎。该患者经典抗中性粒细胞胞浆抗体（c-ANCA）检测为阴性。使用糖皮质激素、环磷酰胺和甲氧苄啶-磺胺甲恶唑治疗已诱导完全缓解。
