Nusynowitz M L, Strader W J
Am J Med Sci. 1975 Nov-Dec;270(3):491-6. doi: 10.1097/00000441-197511000-00010.
The effects of hormonal manipulation on gonadotropin, androgen, and estrogen concentrations in a patient with testicular feminization syndrome (TFS) were studied to clarify the feedback regulation of gonadotropins. Baseline serum LH concentrations were normal to high and FSH concentrations were normal despite markedly elevated plasma testosterone concentrations, implying the lack of a reciprocal control relationship, and fluoxymesterone administration failed to alter gonadotropin or androgenic steroid levels. Clomiphene administration resulted in a rise in both LH and androgen levels, while moderate doses of exogenous estrogens effected a diminution in testosterone but did not significantly alter the levels of gonadotropins. Following gonadectomy, these same doses of estrogens produced a dramatic fall in the very high postoperative levels of gonadotropins. These results suggest that gonadotropin regulation is mediated by estrogens and not directly by androgens in TFS.
为阐明促性腺激素的反馈调节机制，研究了激素调控对一名睾丸女性化综合征（TFS）患者促性腺激素、雄激素和雌激素浓度的影响。尽管血浆睾酮浓度显著升高，但基础血清促黄体生成素（LH）浓度正常至高，促卵泡生成素（FSH）浓度正常，这意味着缺乏相互控制关系，且服用氟甲睾酮未能改变促性腺激素或雄激素类固醇水平。服用克罗米芬导致LH和雄激素水平均升高，而中等剂量的外源性雌激素使睾酮水平降低，但未显著改变促性腺激素水平。性腺切除术后，相同剂量的雌激素使术后非常高的促性腺激素水平急剧下降。这些结果表明，在TFS中，促性腺激素的调节是由雌激素介导的，而非直接由雄激素介导。
