Green J F
Am J Physiol. 1975 Sep;229(3):761-9. doi: 10.1152/ajplegacy.1975.229.3.761.
Mean systemic pressure-flow (Ps-Q) and volume-flow (V-Q) relationships of the systemic vascular bed were determined in two groups of dogs anesthetized with sodium pentobarbital (group I) and with methoxyflurane (group II). All blood returning to the heart (Q) was removed from the right atrial appendage and passed through a Starling resistor, a pump, a flowmeter , and then returned directly into the pulmonary artery. Ps was estimated from plateau values of right atrial pressure obtained during stop-flow procedures. Both the Ps-Q and V-Q relationships were nonlinear. This nonlinearity may be attributed to a redistribution of blood flow between systemic vascular compartments of unequal time constants. With group II, the Ps-Q and V-Q curves were shifted markedly to the right along the Ps and V axes, respectively. Evidence is presented which suggests that this shift was due to an effective back pressure other than right atrial pressure produced by a hepatic waterfall. The beta-adrenergic antagonist practolol increased the effective back pressure and augmented the shift in the Ps-Q and V-Q curves.
在两组分别用戊巴比妥钠麻醉（第一组）和甲氧氟烷麻醉（第二组）的犬中，测定了体循环血管床的平均体循环压力-流量（Ps-Q）和容积-流量（V-Q）关系。所有回心血液（Q）从右心耳引出，通过一个斯塔林电阻器、一个泵、一个流量计，然后直接回流至肺动脉。Ps通过停流过程中获得的右心房压力平台值估算。Ps-Q和V-Q关系均为非线性。这种非线性可能归因于时间常数不等的体循环血管腔室之间血流的重新分布。对于第二组，Ps-Q和V-Q曲线分别沿Ps和V轴显著右移。有证据表明，这种移位是由肝瀑布产生的除右心房压力之外的有效背压所致。β-肾上腺素能拮抗剂心得宁增加了有效背压，并加大了Ps-Q和V-Q曲线的移位。
