马拉维布兰太尔急性胃肠炎患儿中人星状病毒的检测与特征分析

Detection and characterisation of human astroviruses in children with acute gastroenteritis in Blantyre, Malawi.

作者信息

Cunliffe Nigel A, Dove Winifred, Gondwe Jailosi S, Thindwa Benson D M, Greensill Julie, Holmes Jennifer L, Bresee Joseph S, Monroe Stephan S, Glass Roger I, Broadhead Robin L, Molyneux Malcolm E, Hart C Anthony

机构信息

Wellcome Trust Research Laboratories, Universities of Malawi and Liverpool, College of Medicine, Blantyre, Malawi.

出版信息

J Med Virol. 2002 Aug;67(4):563-6. doi: 10.1002/jmv.10139.

DOI:10.1002/jmv.10139

PMID:12116005

Abstract

In a 2-year hospital-based study of paediatric gastroenteritis in Blantyre, Malawi, astroviruses were detected by enzyme immunoassay in 15 (1.9%) of 786 inpatients and in 9 (2.3%) of 400 outpatients. Greater disease severity was noted in children coinfected with human immunodeficiency virus (HIV). Six human astrovirus (HAstV) genotypes were identified, including HAstV-1 (25%), HAstV-2 (21%), HAstV-3 (25%), HAstV-4 (13%), HAstV-5 (4%), and HAstV-8 (13%). Although astroviruses are not major causes of gastroenteritis among children admitted to hospital in Blantyre, concomitant HIV infection appears to be a risk factor for increased severity of disease.

摘要

在马拉维布兰太尔进行的一项为期两年的基于医院的小儿肠胃炎研究中，通过酶免疫测定法在786名住院患者中的15名（1.9%）以及400名门诊患者中的9名（2.3%）检测到星状病毒。在合并感染人类免疫缺陷病毒（HIV）的儿童中观察到疾病严重程度更高。鉴定出六种人类星状病毒（HAstV）基因型，包括HAstV-1（25%）、HAstV-2（21%）、HAstV-3（25%）、HAstV-4（13%）、HAstV-5（4%）和HAstV-8（13%）。虽然星状病毒不是布兰太尔住院儿童肠胃炎的主要病因，但合并HIV感染似乎是疾病严重程度增加的一个危险因素。