意大利患肠胃炎儿童中星状病毒感染的分子流行病学

Molecular epidemiology of astrovirus infection in Italian children with gastroenteritis.

作者信息

De Grazia S, Giammanco G M, Colomba C, Cascio A, Arista S

机构信息

Dipartimento di Igiene e Microbiologia, Università di Palermo, Palermo, Italy.

出版信息

Clin Microbiol Infect. 2004 Nov;10(11):1025-9. doi: 10.1111/j.1469-0691.2004.00995.x.

DOI:10.1111/j.1469-0691.2004.00995.x

PMID:15522011

Abstract

Abstract A 1-year study involving 157 gastroenteritis samples was conducted to investigate the role of human astrovirus (HAstV) as a cause of gastroenteritis in Italian children aged < 2 years. The overall incidence of HAstV was 3.1%. Most cases occurred between March and May, and four of the five isolates were of the HAstV-1 type, the other being HAstV-3. Analysis of genetic variability showed that the three HAstV-1 isolates collected in 2000 clustered together, but separately from the 1999 isolate. The results indicated that HAstV should be considered as a potential diarrhoeal pathogen in Italian children.

摘要

摘要开展了一项为期1年的研究，涉及157份肠胃炎样本，以调查人类星状病毒（HAstV）在意大利2岁以下儿童肠胃炎病因中所起的作用。HAstV的总体发病率为3.1%。大多数病例发生在3月至5月之间，5株分离株中有4株为HAstV-1型，另一株为HAstV-3型。基因变异性分析表明，2000年收集的3株HAstV-1分离株聚在一起，但与1999年的分离株分开。结果表明，HAstV应被视为意大利儿童潜在的腹泻病原体。