感染人类免疫缺陷病毒1型患者的自身免疫性溶血性贫血

Autoimmune hemolytic anemia in patients infected with human immunodeficiency virus-1.

作者信息

Koduri Prasad Rao, Singa Prema, Nikolinakos Petros

机构信息

Hektoen Institute for Medical Research, Department of Medicine, Cook County Hospital, 627 S Wood Street, Chicago, IL 60612, USA.

出版信息

Am J Hematol. 2002 Jun;70(2):174-6. doi: 10.1002/ajh.10096.

DOI:10.1002/ajh.10096

PMID:12116960

Abstract

Four men were diagnosed with human immunodeficiency virus infection (AIDS) and autoimmune hemolytic anemia (HIV-AIHA) during the years 1997-2000 at Cook County Hospital, Chicago. All patients presented with the acute onset of severe hemolytic anemia, fever, and splenomegaly. The direct and indirect antiglobulin tests were positive in all, and three patients had mixed warm and cold autoantibody hemolytic anemia. Two patients responded to prednisone therapy and remain in remission from AIHA for 15 and 30 months, respectively.

摘要

1997年至2000年期间，在芝加哥库克县医院，有四名男子被诊断出感染人类免疫缺陷病毒（艾滋病）并患有自身免疫性溶血性贫血（HIV-AIHA）。所有患者均表现为严重溶血性贫血、发热和脾肿大的急性发作。所有人的直接和间接抗球蛋白试验均呈阳性，三名患者患有温抗体型和冷抗体型混合性自身免疫性溶血性贫血。两名患者对泼尼松治疗有反应，分别从AIHA缓解状态持续了15个月和30个月。