Vasil'ev N V, Mikhailova T N, Vasil'eva O A
Antibiotiki. 1975 Apr;20(4):315-8.
The leucocyte counts in the peripheral blood and titers of the serum lysozyme under conditions of various experimental models were compared. Albino rats, mice, guinea pigs and rabbits exposed to the effect of various factors of a biological and chemical nature were used in the experiments. In addition, observations on humans immunized with bacterial and viral vaccines were analyzed. Development of 3 reaction types was shown to be possible. In the 1st type the dynamics of the lysosome activity and blood leucocyte counts changed in the same way (immunization with smallpox vaccine, listeria infection). Decreased counts of the leucocytes due to the use of cytostatic drugs were accompanied by a parallel decrease in the lysozyme activity. Such variant of the reaction was predominating. The 2nd type of the shifts characterized by an impaired synchronous pattern of the dynamics of the indices was not so frequent (the use of high doses of cytostatics). The 3rd type of the reactions with an exactly opposite character of the shifts in the leucocyte counts and lysozyme activity was observed only as an exclusion. It is concluded that the quantitative dynamics of the leucocytes is not enough by itself for creating an opinion on the nature of the changes in the serum lysozyme. The possible role of macrophages in the above processes is discussed.
比较了各种实验模型条件下外周血白细胞计数和血清溶菌酶滴度。实验中使用了暴露于各种生物和化学性质因素影响下的白化大鼠、小鼠、豚鼠和兔子。此外，还分析了接种细菌和病毒疫苗的人类的观察结果。结果表明可能出现3种反应类型。在第1种类型中，溶酶体活性和血液白细胞计数的动态变化方式相同（接种天花疫苗、感染李斯特菌）。使用细胞抑制药物导致白细胞计数减少的同时，溶菌酶活性也平行下降。这种反应变体占主导地位。第2种类型的变化以指标动态同步模式受损为特征，不太常见（使用高剂量细胞抑制剂）。第3种类型的反应中白细胞计数和溶菌酶活性的变化特征完全相反，仅作为例外情况观察到。得出的结论是，仅白细胞的定量动态不足以对血清溶菌酶变化的性质形成看法。讨论了巨噬细胞在上述过程中的可能作用。
