Sobolev V R, Savkina L N, Efimtseva E P, Kordovich G A
Antibiotiki. 1977 Mar;22(3):242-3.
The dynamics of changes in some indices of the natural immunity of mice treated with EL-Tor vibrio preparations in doses of 50 and 500 gemma/mouse was studied. The blood for analysis was taken from the mice 24 hours, 3, 7 and 10 days after the preparation administration. The results of the study showed that administration of the polysaccharide-containing preparations from El-Tor vibrios in doses of 50 and 500 gemma/mouse was accompanied by some shifts in the regulatory mechanisms: suppression of the serum lysozyme activity on the 1st and 3rd days and its stimulation on the 7th and 10th days. The percentage of phagocytosis and its completeness increased. The indices of phagocytosis and its completeness by the respective periods decreased.
研究了用剂量为50和500个菌苗/小鼠的埃尔托弧菌制剂处理的小鼠自然免疫某些指标的变化动态。在制剂给药后24小时、3天、7天和10天从小鼠采集血液进行分析。研究结果表明，以50和500个菌苗/小鼠的剂量给予含埃尔托弧菌多糖制剂会伴随着调节机制的一些变化：第1天和第3天血清溶菌酶活性受到抑制，而第7天和第10天受到刺激。吞噬作用的百分比及其完整性增加。各时期吞噬作用及其完整性指标下降。
