Zabirov I Sh, Shchepetkina L V
Antibiotiki. 1976 Mar;21(3):246-8.
Activity of lysozyme in the blood serum and leucocytes was determined. The experiments were carried out on albino unbred rats weighing 170 to 200 gm. Benzylpenicillin and oxacillin were administered intramuscularly in doses of 500000 Units/kg or 20000 gamma/kg once every 24 hours for 2, 4 and 6 days. The activity of lysozyme was determined by the turbidimetric and agar-diffusion methods. It was found that the activity of lysozyme in the leucocytes increased by the 5th day accompanied by a simultaneous decrease in its level in the serum followed by reaching the initial values. The data are indicative of the fact that the use of antibiotics in mega-doses is not contraindicated from the point of view of their effect on lysozyme activity.
测定了血清和白细胞中溶菌酶的活性。实验选用体重170至200克的未育白化大鼠进行。苄青霉素和苯唑西林以500000单位/千克或20000微克/千克的剂量，每24小时肌肉注射一次，持续2、4和6天。溶菌酶活性通过比浊法和琼脂扩散法测定。结果发现，白细胞中溶菌酶的活性在第5天增加，同时血清中其水平下降，随后恢复到初始值。这些数据表明，从抗生素对溶菌酶活性的影响来看，大剂量使用抗生素并非禁忌。
